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An ideal antioxidant would have the ability to quench a wid
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An ideal antioxidant would have the ability to quench a wide variety of free radicals, to support the functioning of other antioxidants, to bind or "chelate" metal ions that can generate free radicals, to function in watery and fatty environments, and to be present in tissues, cells, and extracellular spaces. Having exceeded these criteria, Lipoic Acid was termed the "universal antioxidant." As a team, LA and DHLA come close to the ideal, for the following reasons:;1) LA is easily absorbed when consumed orally.;2) LA is readily converted to DHLA in various tissues.;3) As a pair, LA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.;4) LA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.;5) LA and DHLA scavenge free radicals in both fatty and watery environments.;6) DHLA recycles other important antioxidants.;Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which means it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E, and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduced forms. This is necessary to maintain the balance between oxidation and its reverse--the neutralization of free radicals by antioxidants.;DHLA is an essential component in the interaction between these antioxidants, as well as being able to recycle coenzyme Q (CoQ). Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.
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Alpha-lipoic acid (ala, thioctic acid) is a naturally occur
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Alpha-lipoic acid (ala, thioctic acid) is a naturally occurring vitamin-like nutrient that has been intensely investigated as a beneficial agent for a variety of bodily functions involving the nervous, cardiovascular, immune, and detoxification systems. it exists as two enantiomers or stereoisomers: r-(+)-lipoic acid (rla) and s-(-)-lipoic acid (sla). it is produced in small amounts in the liver and other body tissues, where it is needed by enzymes to catalyze numerous essential chemical reactions in the body. for instance, ala is essential inside the mitochondria of cells, where it is needed to metabolize glucose and direct calories into energy production.ala is considered to be a multimodal supplement because, aside from its enzymatic role in energy production, it acts by multiple mechanisms and displays diverse health-enhancing and antioxidant properties. recently discovered is ala's ability to regulate several genes linked to cell survival and oxidative stress. therefore, in addition to its enzymatic role, ala is a powerful antioxidant and performs a number of other vital functions related to its ability to modify the expression of various genes. supplementing with ala is, therefore, not so much a direct benefit to cells, but rather an indirect aid that effectively "kick starts" declining function, helping cells recover functionality that came more easily and naturally in youth.
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Alpha-lipoic acid (ala, thioctic acid) is a naturally occur
... Read more
Alpha-lipoic acid (ala, thioctic acid) is a naturally occurring vitamin-like nutrient that has been intensely investigated as a therapeutic agent for a variety of conditions involving the body's nervous, cardiovascular, immune, and detoxification systems. it exists as two enantiomers or stereoisomers: r-(+)-lipoic acid (rla) and s-(-)-lipoic acid (sla). it is produced in small amounts in the liver and other body tissues, where it is needed by enzymes to catalyze numerous essential chemical reactions in the body. for instance, ala is essential inside the mitochondria of cells, where it is needed to metabolize glucose and direct calories into energy production.ala is considered to be a multimodal supplement because, aside from its enzymatic role in energy production, it acts by multiple mechanisms and displays diverse pharmacologic and antioxidant properties. recently discovered is ala's ability to switch the regulation of several genes linked to cell survival, inflammation and oxidative stress. so in addition to its enzymatic role, ala is a powerful antioxidant and performs a number of other vital functions related to its ability to modify the expression of various genes. ala is therefore not so much a direct benefit to cells, but rather an indirect aid that "kick starts" declining function in cells, helping them recover the functions that came more easily and naturally in the young.
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